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you can have a quill rat drop a colossus blade without any problems if you modify the quill rat treasureclass accordingly. There is no limit to what item can be dropped by which monster.
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if the treasureclasses "weapXX" and "armoXX" exist, where XX is a number between 03 and 99 and dividable by 3). This is completely handled by treasureclassex.txt (and a little bit by itemtypes.txt, where you can set if a certain type is a treasureclass, i.e.
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